HRID1486067

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1ccc2ccccc2c1CN1C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)[C@H](C)N(C(C)=O)c2ccccc21

HCID118292612

未命名化合物

PRODUCTS

生成物

结构：CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3ccccc23)c2ccccc2N(C(C)=O)[C@H]1C.Cl

HCID90082418

未命名化合物

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A rt suspension of tert-butyl(S)-1-((2S,3S)-1-acetyl-5-((2-methoxynaphthalen-1-yl)methyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylamino)-1-oxopropan-2-yl(methyl)carbamate (49.8 mg, 84.6 μmol) in 4 M HCl in dioxane (423 μl) was stirred for 2 h. The reaction was diluted with Et2O and the solids were collected by vacuum filtration, taken up in MeCN—H2O, and lyophilized to provide (S)-N-((2S,3S)-1-acetyl-5-((2-methoxynaphthalen-1-yl)methyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride (32.4 mg, 73%) as a white solid. MS m/z 489 (MH)+.

WORKUP

后处理

filtrationthe solids were collected by vacuum filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-45894932269747dd81dd9839c3e697de
来源数据集: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09422331B2
来源说明: uspto-grants-2016_08

反应 SMILES

[C:1]([N:4]1[C@@H:10]([CH3:11])[C@H:9]([NH:12][C:13](=[O:25])[C@@H:14]([N:16](C)[C:17](=O)OC(C)(C)C)[CH3:15])[C:8](=[O:26])[N:7]([CH2:27][C:28]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=[CH:30][C:29]=2[O:38][CH3:39])[C:6]2[CH:40]=[CH:41][CH:42]=[CH:43][C:5]1=2)(=[O:3])[CH3:2].[ClH:44]>O1CCOCC1.CCOCC>[ClH:44].[C:1]([N:4]1[C@@H:10]([CH3:11])[C@H:9]([NH:12][C:13](=[O:25])[C@@H:14]([NH:16][CH3:17])[CH3:15])[C:8](=[O:26])[N:7]([CH2:27][C:28]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=[CH:30][C:29]=2[O:38][CH3:39])[C:6]2[CH:40]=[CH:41][CH:42]=[CH:43][C:5]1=2)(=[O:3])[CH3:2]