反应详情

Intermediate 82 was dissolved in 200 mL of 48% aqueous HBr and the mixture heated to reflux for 2 hours. The Solvent was removed by rotary evaporation. The residue was taken up in 100 mL of ethanol and the solvent again removed. This was repeated twice more to remove residual water. LC-MS showed the product was >90% pure had the expected M+H+ of 156.

1. temperaturethe mixture heated
2. temperatureto reflux for 2 hours
3. customThe Solvent was removed by rotary evaporation
4. customthe solvent again removed
5. customto remove residual water