反应详情

A rt suspension of tert-butyl(3S,4S)-7-cyano-1-((3-cyclopropylquinolin-4-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylcarbamate (134 mg, 269 μmol) in 4 M HCl in dioxane (1.35 ml) was stirred for 2.5 h. The reaction was diluted with Et2O and the solids were collected by vacuum filtration to provide (3S,4S)-3-amino-1-((3-cyclopropylquinolin-4-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carbonitrile dihydrochloride (127 mg, quant.) as an off-white solid. MS m/z 398 (MH)+.

1. filtrationthe solids were collected by vacuum filtration