Hydrochloric Acid → HCID 178462035, compound

HRID 1486184Notes

Reaction equation

HRID 1486184 reaction equation
C(OC([NH:8][C@@H:9]([CH3:48])[CH2:10][NH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([CH2:18][C:19]([NH:21][C@H:22]([B:35]2[O:43]C3C(C)(C4CC(C3)C4(C)C)[O:36]2)[CH2:23][C:24]2[C:25](OC)=[C:26]([CH:30]=[CH:31][CH:32]=2)[C:27]([OH:29])=[O:28])=[O:20])[CH2:14][CH2:13]1)=O)(C)(C)C.Cl>>[NH2:8][C@@H:9]([CH3:48])[CH2:10][NH:11][C@H:12]1[CH2:13][CH2:14][C@H:15]([CH2:18][C:19]([NH:21][C@H:22]2[CH2:23][C:24]3[CH:32]=[CH:31][CH:30]=[C:26]([C:27]([OH:29])=[O:28])[C:25]=3[O:36][B:35]2[OH:43])=[O:20])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178491871HCID 178491871, compound

Product 1

HCID 178462035HCID 178462035, compound

Procedure

To 3-((2R)-2-(2-(trans-4-((S)-2-(tert-butoxycarbonylamino)propylamino) cyclohexyl)acetamido)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)ethyl)-2-methoxybenzoic acid from Step 2 in a flask was added 3N aqueous HCl and the reaction mixture was stirred at refluxing for 1 hr. The product was purified using reverse phase HPLC and dried using lyophilization. ESI-MS m/z 409 (MH)+.

Workup

  1. temperatureat refluxing for 1 hr
  2. customThe product was purified
  3. customdried

Sources & evidence

ORD record
ord-a18de11564f94f5bbcb3e75ba1b45b70
Source dataset
uspto-grants-2016_08
Patent number
US09422314B2

Reaction notes

Loading…