反应详情

温度

90 °C

A solution of 0.440 g (1.22 mmol, 1 eq.) of ethyl 7-[(2,6-difluorobenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylate from Example 3A in 12.7 ml of dioxane was admixed with 4.9 ml (4.88 mmol, 4.0 eq.) of 1 N aqueous sodium hydroxide solution and the mixture was stirred at 90° C. for 36 h. Subsequently, the reaction mixture was concentrated and the precipitated solids were filtered off. The filtrate was acidified with 6 N aqueous hydrochloric acid and stirred briefly, and the precipitated solids were filtered off, washed with water and dried. 248 mg of the title compound were obtained (61% of theory, 60% purity), which was converted further without further purification.

1. concentrationSubsequently, the reaction mixture was concentrated
2. filtrationthe precipitated solids were filtered off
3. stirringstirred briefly
4. filtrationthe precipitated solids were filtered off
5. washwashed with water
6. customdried