Sodium Hydroxide → HCID 117859510, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.440 g (1.22 mmol, 1 eq.) of ethyl 7-[(2,6-difluorobenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylate from Example 3A in 12.7 ml of dioxane was admixed with 4.9 ml (4.88 mmol, 4.0 eq.) of 1 N aqueous sodium hydroxide solution and the mixture was stirred at 90° C. for 36 h. Subsequently, the reaction mixture was concentrated and the precipitated solids were filtered off. The filtrate was acidified with 6 N aqueous hydrochloric acid and stirred briefly, and the precipitated solids were filtered off, washed with water and dried. 248 mg of the title compound were obtained (61% of theory, 60% purity), which was converted further without further purification.

Provenance & Evidence