反应详情

温度

90 °C

700 mg (1.81 mmol) of ethyl 2,5-dimethyl-7-[(2,3,6-trifluorobenzyl)oxy]pyrazolo[1,5-a]pyridine-3-carboxylate from Example 9A were initially charged in 18 ml of dioxane and heated to 90° C. 4.5 ml of dioxane and 7.25 ml (14.50 mmol) of 2 N aqueous sodium hydroxide solution were added, and the reaction mixture was stirred at 90° C. for two days. Another 3.63 ml (7.26 mmol) of 2 N aqueous sodium hydroxide solution were added and the mixture was stirred at 90° C. for a further 2 hours. The reaction solution was admixed with 15 ml of 1 N aqueous hydrochloric acid and stirred for 30 min. In the course of this, solids precipitated out. This suspension was filtered, and the solids filtered off were washed with a little water and dried under high vacuum. 358 mg of the target compound were obtained (54% of theory).

1. stirringthe mixture was stirred at 90° C. for a further 2 hours
2. stirringstirred for 30 min
3. customIn the course of this, solids precipitated out
4. filtrationThis suspension was filtered
5. filtrationthe solids filtered off
6. washwere washed with a little water
7. customdried under high vacuum