Hydrochloric Acid → HCID 90232292, compound

HRID 1486251Notes

Reaction equation

HRID 1486251 reaction equation
[F:1][C:2]([F:18])([F:17])[CH:3]1[CH2:8][CH:7]([NH:9]C(=O)OC(C)(C)C)[CH2:6][CH2:5][NH:4]1.[ClH:19]>C(OCC)C>[ClH:19].[F:18][C:2]([F:1])([F:17])[CH:3]1[CH2:8][CH:7]([NH2:9])[CH2:6][CH2:5][NH:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21054731HCID 21054731, compound

Product 1

HCID 90232292HCID 90232292, compoundYield 101.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

115 mg (0.43 mmol) of tert-butyl [2-(trifluoromethyl)piperidin-4-yl]carbamate were initially charged in 2.2 ml of diethyl ether, 2.14 ml (4.28 mmol) of 2 N hydrochloric acid in diethyl ether were added and the mixture was stirred at RT overnight. The reaction mixture was concentrated and the residue was dried under high vacuum. 89 mg of the target compound were obtained (101% of theory).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under high vacuum

Sources & evidence

ORD record
ord-38be0c1ca2034475afbab1f972ef7096
Source dataset
uspto-grants-2016_08
Patent number
US09422285B2

Reaction notes

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