Hydrochloric Acid → HCID 88415079, compound

HRID 1486261Notes

Reaction equation

HRID 1486261 reaction equation
[NH2:1][C:2]([CH3:16])([C:12]([F:15])([F:14])[F:13])[CH2:3][NH:4]C(=O)OC(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[ClH:17].[F:13][C:12]([F:15])([F:14])[C:2]([CH3:16])([NH2:1])[CH2:3][NH2:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 901360511609346-06-6

Product 1

HCID 88415079HCID 88415079, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

15 g (61.9 mmol) of rac-tert-butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate from Example 51A in dioxane (188 ml) were admixed with 188 ml of 4 M hydrogen chloride in dioxane. The reaction mixture was stirred at RT for 16 h, then concentrated and stored under argon. This gave 14.4 g (108% of theory) of the target compound, which was not purified any further.

Workup

  1. concentrationconcentrated
  2. customThis gave 14.4 g (108% of theory) of the target compound, which was not purified any further

Sources & evidence

ORD record
ord-97e5fa5daa2b487693a6cc4234586815
Source dataset
uspto-grants-2016_08
Patent number
US09422285B2

Reaction notes

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