反应详情

温度

90 °C

A solution of 169 mg (0.43 mmol; about 95% purity) of methyl 7-[(2,6-difluorobenzyl)oxy]-5-methyl-2-propylpyrazolo[1,5-a]pyridine-3-carboxylate from Example 96A in 4.5 ml of dioxane was admixed with 2.6 ml (2.6 mmol) of 1 N sodium hydroxide solution and reacted at 90° C. for 24 h. Subsequently, another 0.5 ml (0.5 mmol) of 1 N sodium hydroxide solution were added and the mixture was stirred at 90° C. for 1 h. The reaction solution was cooled and adjusted to pH 2 with 1 N hydrochloric acid. The solids that precipitated out were filtered off and dried under high vacuum. 180 mg of the title compound (72% by LC-MS, 84% of theory) were obtained and were converted without further purification.

1. customreacted at 90° C. for 24 h
2. temperatureThe reaction solution was cooled
3. customThe solids that precipitated out
4. filtrationwere filtered off
5. customdried under high vacuum