反应详情

温度

100 °C

A solution of 220 mg (0.469 mmol, 71% pure) of 7-(cyclohexylmethoxy)-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester from Example 119A in 4 ml of dioxane was admixed with 2 ml of 2 N sodium hydroxide solution. The resulting mixture was stirred at 100° C. for 15 h. The solvent was drawn off under reduced pressure and acetonitrile (5 ml) was added to the residue, and then trifluoroacetic acid (2 ml) was added dropwise. The resulting precipitate was filtered off and dried under reduced pressure, which gave 110 mg (74% of theory, 95% pure) of the target compound.

1. additionwas added to the residue
2. filtrationThe resulting precipitate was filtered off
3. customdried under reduced pressure, which
4. customgave 110 mg (74% of theory, 95% pure) of the target compound