反应详情

64.21 g (294.18 mmol) of di-tert-butyl dicarbonate were initially charged in a round-bottom flask, and 30 g (267.44 mmol) of rac-2-amino-2-methylpentanenitrile were added very gradually at RT (internal thermometer, maximum temperature 30° C.), and stirring of the mixture was continued at room temperature overnight. The reaction mixture was admixed with dichloromethane and washed twice with 1 N sodium hydroxide solution. The organic phase was dried over sodium sulphate, filtered and concentrated (at bath temperature 30° C.). 76.33 g (quantitative yield) of the target compound were obtained.

1. washwashed twice with 1 N sodium hydroxide solution
2. dry with materialThe organic phase was dried over sodium sulphate
3. filtrationfiltered
4. concentrationconcentrated (at bath temperature 30° C.)