Trifluoroacetic acid → rac-N-(2-Amino-2-methylpentyl)-7-[(2,6-difluoro-3-methoxybenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxamide

Participants

Reaction Steps

rac-{1-[({7-[(2,6-Difluoro-3-methoxybenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]-pyridin-3-yl}carbonyl)amino]-2-methylpentan-2-yl}carbamic acid tert-butyl ester (Example 125A) in 4 ml of dichloromethane was admixed with 3 ml of trifluoroacetic acid. The resulting solution was stirred at room temperature for 3 h. After the reaction had ended, the solvent was drawn off under reduced pressure and the residue was purified by preparative HPLC chromatography (Method 21), which gave 10 mg (11% of theory, over 2 stages) of the target compound.

Provenance & Evidence