反应详情

A solution of 40 mg (0.073 mmol) of rac-{1-[({7-[(2-difluorobenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridin-3-yl}carbonyl)amino]-2-methylpentan-2-yl}carbamic acid tert-butyl ester (Example 138A) in 2 ml of dichloromethane was admixed with 0.113 ml of trifluoroacetic acid. The resulting mixture was stirred at room temperature for 18 hours and then heated to 40° C. Further trifluoroacetic acid (0.169 ml) was added in portions over the course of 3 hours. The reaction mixture was concentrated under reduced pressure and the remaining residue was purified by preparative HPLC chromatography (Method 21), which gave 11.0 mg (33% yield) of the target compound.

1. temperatureheated to 40° C
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe remaining residue was purified by preparative HPLC chromatography (Method 21), which