反应详情

温度

100 °C

A mixture of Compound 13 (1.00 g, 2.28 mmol), 2,2′-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(benzo[d]oxazole) (1.159 g, 2.37 mmol), tetrakis(triphenylphosphine) palladium(0) (0.13 g, 0.11 mmol), potassium carbonate (0.95 g, 6.85 mmol), 1,4-dioxane (20.00 mL), and water (4.00 mL) was degassed with bubbling argon for 20 minutes at 45° C. The reaction was then heated to 100° C. and stirred overnight (16.5 hours), maintaining an argon atmosphere. The precipitated product was filtered, dried, and performed boiling ethyl acetate, chloroform, and methanol washes. The solid product was collected to yield Host-7 (0.75 g, 45%). Confirmed by LCMS (APCI): calculated for C50H29N3O3 (M+H): 720. Found: 720.

1. customwas degassed with bubbling argon for 20 minutes at 45° C
2. temperaturemaintaining an argon atmosphere
3. filtrationThe precipitated product was filtered
4. customdried
5. customThe solid product was collected
6. customto yield Host-7 (0.75 g, 45%)