Estradiol → Tetrahydrofuran toluene

HRID 1486459Notes

Reaction equation

HRID 1486459 reaction equation
[CH3:1][C@@:2]12[C@@H](O)CC[C@H:15]1[C@H:14]1[C@@H:5]([C:6]3C=C[C:9]([OH:20])=[CH:10][C:11]=3CC1)[CH2:4][CH2:3]2.C1COCC1>C1(C)C=CC=CC=1>[C:2]1([CH3:1])[CH:15]=[CH:14][CH:5]=[CH:4][CH:3]=1.[CH2:10]1[CH2:9][O:20][CH2:6][CH2:11]1

Participants

4

Reactant 2

HCID 5757Estradiol3×HCID 8028Tetrahydrofuran2×

Product 1

HCID 22635083Tetrahydrofuran toluene

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

Estradiol was combined with THF. Two parts by weight of polyethylenevinylacetate (PEVA) was combined with five parts by weight of poly-n-butyl methacrylate (PBMA) in toluene. The estradiol solution was combined with the PEVA/PBMA solution to form a coating solution containing 30 mg/ml total solids (30 wt. % estradiol, 20 wt. % PEVA, and 50 wt. % PBMA) and a solvent containing 80% toluene and 20% THF. The resulting solution had an estradiol concentration that was less than the saturation point for a solvent of 80% toluene and 20% THF at ambient temperature (approximately 21-22° C.). The distinction between this example and example 4 is that here the total solids concentration was only 30 mg/ml instead of 40 mg/ml. Thus the concentration of estradiol was at less than the saturation point.

Workup

  1. customto form a coating solution
  2. concentrationan estradiol concentration that
  3. customwas less than the saturation point for a solvent of 80% toluene and 20% THF at ambient temperature
  4. custom(approximately 21-22° C.)
  5. concentrationthe total solids concentration

Sources & evidence

ORD record
ord-eabc6cb049c44468a0e03fa92aabe26d
Source dataset
uspto-grants-2016_08
Patent number
US09427501B2

Reaction notes

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