Trifluoroacetic acid → HCID 86698935, Verbindung

HRID 1486460Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1486460
[O:1]=[C:2]([CH2:49][CH2:50][CH2:51][C:52](=[O:72])[NH:53][C:54]1[CH:55]=[N:56][C:57]([C:60]2[N:61]=[N:62][C:63]([C:66]3[CH:71]=[CH:70][CH:69]=[CH:68][N:67]=3)=[N:64][N:65]=2)=[CH:58][CH:59]=1)[NH:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][C:42]([O:44]C(C)(C)C)=[O:43].C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:1]=[C:2]([CH2:49][CH2:50][CH2:51][C:52](=[O:72])[NH:53][C:54]1[CH:55]=[N:56][C:57]([C:60]2[N:61]=[N:62][C:63]([C:66]3[CH:71]=[CH:70][CH:69]=[CH:68][N:67]=3)=[N:64][N:65]=2)=[CH:58][CH:59]=1)[NH:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][C:42]([OH:44])=[O:43]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86698936HCID 86698936, Verbindung

Produkt 1

HCID 86698935HCID 86698935, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 3 (160 mg, 0.157 mmol) in anhydrous DCM (2 mL) under nitrogen atmosphere was added TFA (2 mL). The reaction mixture was stirred for 2 hours at room temperature and evaporated to dryness. The residue was redissolved in dry DCM (2 ml) and again treated with TFA (2 mL) for 2 hours. This process was repeated once more. Finally, the reaction mixture was evaporated to dryness and co-evaporated twice with DCM furnishing the deprotected product 4 in quantitative yield.

Aufarbeitung

  1. customevaporated to dryness
  2. dissolutionThe residue was redissolved in dry DCM (2 ml)
  3. additionagain treated with TFA (2 mL) for 2 hours
  4. customFinally, the reaction mixture was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-cb9234b744654160b2207c209bf8dbb0
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09427482B2

Notizen zur Reaktion

Wird geladen…