反应详情

tert-Butyl-N-({trans-4-[(8-fluoroquinolin-4-yl)oxy]cyclohexyl}methyl)carbamate (950 mg, 2.54 mmol) was dissolved in dichloromethane (7.0 mL) and trifluoroacetic acid (2.0 mL, 25.4 mmol) was added at room temperature. After one hour at room temperature the reaction mixture was concentrated by evaporation and was then coevaporated with toluene. The residue was taken up in ammoniacal methanol solution (7 N) and concentrated by evaporation again to dryness. After chromatography, the desired product was obtained at 68% yield (470 mg).

1. concentrationAfter one hour at room temperature the reaction mixture was concentrated by evaporation
2. concentrationconcentrated by evaporation again to dryness