反应详情

Intermediate 85 was coupled with pyridine 4-carboxaldehyde following procedure E. The product was purified by HPLC. LC-MS showed the product had the expected M+H+ of 557. 1H NMR (Varian 300 MHz, DMSO, shifts relative to the solvent peak at 2.50 ppm) δ 8.4 (d, 2H), 8.2 (d, 1H), 8.1 (s, 1H), 7.8 (d, 1H), 7.4-7.3 (m, 2H), 7.2-7.1 (m, 3H), 7.0 (d, 1H), 6.9 (d, 1H), 6.8 (d, 1H), 3.6 (s, 4H), 3.4 (d, 2H), 3.1 (d, 2H), 2.7 (m, 3H), 1.9-1.8 (m, 4H), 1.6-1.4 (m, 4H), 0.94 (t, 3H).

1. customThe product was purified by HPLC