4-(Bromomethyl)-5-methyl-1,3-dioxol-2-one → HCID 72550764, Verbindung

HRID 1486680Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1486680
C(OC([N:7]1[C@:11]2([C@@H:16]([F:17])[CH2:15][C@@H:14]3[C@H:12]2[C@H:13]3[C:18]([OH:20])=[O:19])[C:10](=[O:21])[O:9]C1)=O)C=C.Br[CH2:23][C:24]1[O:25][C:26](=[O:30])[O:27][C:28]=1[CH3:29]>>[NH2:7][C@@:11]1([C:10]([OH:9])=[O:21])[C@@H:16]([F:17])[CH2:15][C@@H:14]2[C@H:12]1[C@H:13]2[C:18]([O:20][CH2:23][C:24]1[O:25][C:26](=[O:30])[O:27][C:28]=1[CH3:29])=[O:19]

Komponenten

3

Edukt 2

HCID 107741414-(Bromomethyl)-5-methyl-1,3-dioxol-2-oneHCID 117987522(1S,2S,3S,5R,6S)-3'-((allyloxy)carbonyl)-3-fluoro-5'-oxospiro[bicyclo[3.1.0]hexan-2,4'-oxazolidine]-6-carboxylic acid

Produkt 1

HCID 72550764HCID 72550764, VerbindungAusbeute 27 %

Versuchsvorschrift

(1S,2S,3S,5R,6S)-3′-((Allyloxy)carbonyl)-3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-6-carboxylic acid (A-1-2, 660 mg) and 4-(bromomethyl)-5-methyl-1,3-dioxol-2-one (639 mg) were treated in the same manner as in Example A-1 (3) and (4) to give the title compound (A-16, 188 mg) as a pale yellow solid.

Quellen und Nachweise

ORD-Eintrag
ord-5832ca116eea48898d6bdac2976fd5eb
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428483B2

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