Ethanol → 2-Bromo-1-(diethoxymethyl)-4-fluorobenzene

HRID 148669Notes

Reaction equation

HRID 148669 reaction equation
[Br:11][c:12]1[cH:13][c:14]([F:15])[cH:16][cH:17][c:18]1[CH3:19].[Br:1][c:2]1[c:3]([CH:4]=[O:5])[cH:6][cH:7][c:8]([F:10])[cH:9]1.[CH2:20]([O:21][CH:23]([O:24][CH2:25][CH3:26])[O:27][CH2:28][CH3:29])[CH3:22].[CH3:41][CH2:42][OH:43].[Na+:44].[Na+:45].[O-:46][C:47](=[O:48])[O-:49].[c:30]1([CH3:31])[cH:32][cH:33][c:34]([S:35]([OH:36])(=[O:37])=[O:38])[cH:39][cH:40]1>>[Br:1][c:2]1[c:3]([CH:23]([O:24][CH2:25][CH3:26])[O:27][CH2:28][CH3:29])[cH:6][cH:7][c:8]([F:10])[cH:9]1

Participants

8

Reactant 7

HCID 702EthanolHCID 923Sodium ion2×HCID 6101p-Toluenesulfonic acidHCID 19660Carbonate IonHCID 31214Ethyl orthoformateHCID 740162-Bromo-4-fluorotolueneHCID 27733192-Bromo-4-fluorobenzaldehyde

Product 1

HCID 183576052-Bromo-1-(diethoxymethyl)-4-fluorobenzene

Sources & evidence

ORD record
ord-519686fa07c444798e87be8f15c3e517
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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