HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-tert-butylpiperidine-4-carboxamide → 1-(3-Amino-5-bromo-benzyl)-piperidine-4-carboxylic acid tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-tert-butylpiperidine-4-carboxamide | HCID 7175833 | — |
| Reactant | 3-Bromo-5-nitrobenzaldehyde | HCID 16743966 | — |
| Product | 1-(3-Amino-5-bromo-benzyl)-piperidine-4-carboxylic acid tert-butylamide | HCID 86706532 | — |
Reaction Steps
The title compound is prepared according to the reactions described above starting from 3-bromo-5-nitro-benzaldehyde and piperidine-4-carboxylic acid tert-butylamide yielding after reductive amination BB-10a; LC-MS A: tR=0.65 min; [M+H]+=398.00 followed by reduction with stannous chloride the title compound; LC-MS A: tR=0.60 min; [M+H]+=369.67.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-44ecdcb15d0e4960801a9bb406124468 |
| Source note | uspto-grants-2016_08 |