HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-tert-butylpiperidine-4-carboxamide → 1-(5-Amino-2-methyl-benzyl)-piperidine-4-carboxylic acid tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-tert-butylpiperidine-4-carboxamide | HCID 7175833 | — |
| Reactant | 2-Methyl-5-nitrobenzaldehyde | HCID 12654145 | — |
| Reactant | 1-(2-Methyl-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide | HCID 86706536 | — |
| Product | 1-(5-Amino-2-methyl-benzyl)-piperidine-4-carboxylic acid tert-butylamide | HCID 86706535 | — |
Reaction Steps
The title compound is prepared according to the reactions described for BB-5 above starting from 2-methyl-5-nitro-benzaldehyde and piperidine-4-carboxylic acid tert-butylamide yielding after reductive amination 1-(2-methyl-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide; LC-MS A: tR=0.62 min; [M+H]+=334.21 followed by reduction with stannous chloride the title compound; LC-MS A: tR=0.44 min; [M+H]+=304.28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-43010248afc84310995d8406544eb9d5 |
| Source note | uspto-grants-2016_08 |