HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-nitrobenzaldehyde → 1-(3-Amino-2-methyl-benzyl)-piperidine-4-carboxylic acid tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-nitrobenzaldehyde | HCID 262241 | — |
| Reactant | N-tert-butylpiperidine-4-carboxamide | HCID 7175833 | — |
| Reactant | 1-(2-Methyl-3-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide | HCID 86706542 | — |
| Product | 1-(3-Amino-2-methyl-benzyl)-piperidine-4-carboxylic acid tert-butylamide | HCID 86706541 | — |
Reaction Steps
The title compound is prepared according to the reactions described for BB-5 above starting from 2-methyl-3-nitro-benzaldehyde and piperidine-4-carboxylic acid tert-butylamide yielding after reductive amination 1-(2-methyl-3-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide; LC-MS A: tR=0.62 min; [M+H]+=334.32 followed by reduction with stannous chloride the title compound; LC-MS A: tR=0.45 min; [M+H]+=304.32.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-5a738ab3b67b44d9919c4871ac6eb3c4 |
| Source note | uspto-grants-2016_08 |