(5-Amino-2-fluorophenyl)methanol → N-(4-Fluoro-3-formyl-phenyl)-5-methyl-nicotinamide

HRID 1486743Notes

Reaction equation

HRID 1486743 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7](Cl)=[O:8].[NH2:11][C:12]1[CH:13]=[CH:14][C:15]([F:20])=[C:16]([CH2:18][OH:19])[CH:17]=1>>[F:20][C:15]1[CH:14]=[CH:13][C:12]([NH:11][C:7](=[O:8])[C:6]2[CH:10]=[C:2]([CH3:1])[CH:3]=[N:4][CH:5]=2)=[CH:17][C:16]=1[CH:18]=[O:19]

Participants

3

Reactant 2

HCID 2737680(5-Amino-2-fluorophenyl)methanolHCID 145380555-Methylnicotinoyl chloride

Product 1

HCID 86706562N-(4-Fluoro-3-formyl-phenyl)-5-methyl-nicotinamide

Procedure

The title compound is prepared according to the reaction sequence described above using 5-methylnicotinoyl chloride and (5-amino-2-fluorophenyl)methanol followed by oxidation of the crude alcohol: LC-MS A: tR=0.60 min; [M+H]+=258.88.

Sources & evidence

ORD record
ord-57c10caf981c4297887f6064e3b635df
Source dataset
uspto-grants-2016_08
Patent number
US09428456B2

Reaction notes

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