HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Amino-2-fluorophenyl)methanol → N-(4-Fluoro-3-formyl-phenyl)-5-methyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Amino-2-fluorophenyl)methanol | HCID 2737680 | — |
| Reactant | 5-Methylnicotinoyl chloride | HCID 14538055 | — |
| Product | N-(4-Fluoro-3-formyl-phenyl)-5-methyl-nicotinamide | HCID 86706562 | — |
Reaction Steps
The title compound is prepared according to the reaction sequence described above using 5-methylnicotinoyl chloride and (5-amino-2-fluorophenyl)methanol followed by oxidation of the crude alcohol: LC-MS A: tR=0.60 min; [M+H]+=258.88.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09428456B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-57c10caf981c4297887f6064e3b635df |
| Source note | uspto-grants-2016_08 |