5-Fluoropyridine-2-carbonyl chloride → 5-Fluoro-pyridine-2-carboxylic acid (3-[1,3]dioxolan-2-yl-phenyl)-amide

HRID 1486744Notes

Reaction equation

HRID 1486744 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[C:8]([NH:12]C(=O)C2C=C(C)C=NC=2)[CH:9]=[CH:10][CH:11]=1.[F:22][C:23]1[CH:24]=[CH:25][C:26]([C:29](Cl)=[O:30])=[N:27][CH:28]=1>>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[C:8]([NH:12][C:29]([C:26]2[CH:25]=[CH:24][C:23]([F:22])=[CH:28][N:27]=2)=[O:30])[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 219426985-Fluoropyridine-2-carbonyl chlorideHCID 86706559N-(3-[1,3]Dioxolan-2-yl-phenyl)-5-methyl-nicotinamide

Product 1

HCID 1317368155-Fluoro-pyridine-2-carboxylic acid (3-[1,3]dioxolan-2-yl-phenyl)-amide

Procedure

The subtitle compound is prepared according to the reaction 4.01a described above using 5-fluoropicolinoyl chloride: LC-MS A: tR=0.89 min; [M+H]+=289.29.

Sources & evidence

ORD record
ord-512f412116204f64b59a43b7c42f6a65
Source dataset
uspto-grants-2016_08
Patent number
US09428456B2

Reaction notes

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