Trifluoroacetic acid → HCID 178512537, compound

HRID 1486861Notes

Reaction equation

HRID 1486861 reaction equation
[NH:1]([C:5]1[CH:40]=[CH:39][C:8]([C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]3[CH2:22][C:21]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])([CH2:23][C:24](=[O:30])[O:25]C(C)(C)C)[O:20][N:19]=3)[CH:13]=2)=[O:10])=[CH:7][CH:6]=1)[C:2]([NH2:4])=[NH:3].[C:41]([OH:47])([C:43]([F:46])([F:45])[F:44])=[O:42]>>[F:44][C:43]([F:46])([F:45])[C:41]([OH:47])=[O:42].[NH:1]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][C:12]2[CH:13]=[C:14]([C:18]3[CH2:22][C:21]([CH2:31][C:32]([OH:34])=[O:33])([CH2:23][C:24]([OH:30])=[O:25])[O:20][N:19]=3)[CH:15]=[CH:16][CH:17]=2)=[O:10])=[CH:39][CH:40]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178450896HCID 178450896, compound

Product 1

HCID 178512537HCID 178512537, compound

Procedure

A mixture of 3-(5,5-bis(2-tert-butoxy-2-oxoethyl)-4,5-dihydro-1,2-oxazol-3-yl)phenyl 4-carbamimidamidobenzoate (94.1 mg) and TFA (1 mL) was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and then, the residue was washed with diethyl ether to obtain the title compound (63.3 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-b9696fa70eed49e5b0878ed062c7285c
Source dataset
uspto-grants-2016_08
Patent number
US09428470B2

Reaction notes

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