Ammonium Acetate → HCID 178512536, compound

HRID 1486862Notes

Reaction equation

HRID 1486862 reaction equation
FC(F)(F)C(O)=O.[NH:8]([C:12]1[CH:39]=[CH:38][C:15]([C:16]([O:18][C:19]2[CH:20]=[C:21]([C:25]3[CH2:29][C:28]([CH2:34][C:35]([OH:37])=[O:36])([CH2:30][C:31]([OH:33])=[O:32])[O:27][N:26]=3)[CH:22]=[CH:23][CH:24]=2)=[O:17])=[CH:14][CH:13]=1)[C:9]([NH2:11])=[NH:10].C([O-])(=O)C.[NH4+]>O>[NH:8]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([O:18][C:19]2[CH:20]=[C:21]([C:25]3[CH2:29][C:28]([CH2:34][C:35]([OH:37])=[O:36])([CH2:30][C:31]([OH:33])=[O:32])[O:27][N:26]=3)[CH:22]=[CH:23][CH:24]=2)=[O:17])=[CH:38][CH:39]=1)[C:9]([NH2:11])=[NH:10]

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 178512537HCID 178512537, compound

Product 1

HCID 178512536HCID 178512536, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

2,2′-(3-(3-((4-Carbamimidamidobenzoyl)oxy)phenyl)-4,5-dihydro-1,2-oxazole-5,5-diyl)diacetic acid trifluoroacetate (40.9 mg) was suspended in water (1 mL), and an aqueous solution prepared from ammonium acetate (17.06 mg) and water (1 mL) was added to the suspension at room temperature. The obtained mixture was stirred at room temperature for 1 hour, and then, the solid was collected by filtration and washed with water and acetone to obtain the title compound (28.4 mg).

Workup

  1. additionwas added to the suspension at room temperature
  2. filtrationthe solid was collected by filtration
  3. washwashed with water and acetone

Sources & evidence

ORD record
ord-288273d9aa624506a5ffc90c6a9f96f4
Source dataset
uspto-grants-2016_08
Patent number
US09428470B2

Reaction notes

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