反应详情

To a stirred solution of 2-methyl-2-(3-nitrophenyl)propanamide (0.9 g, 4.32 mmol) in methanol was added Pd—C (10%, 0.23 g) followed by slow addition of triethylsilane (6.90 ml, 43.2 mmol) at RT. Reaction was stirred at same temperature for 25 min. The reaction mixture was filtered through celite bed and washed with methanol (50 ml). Filtrate was collected and concentrated under vacuum to obtain 2-(3-aminophenyl)-2-methylpropanamide (0.611 g).

1. customReaction
2. filtrationThe reaction mixture was filtered through celite bed
3. washwashed with methanol (50 ml)
4. customFiltrate was collected
5. concentrationconcentrated under vacuum