Ammonia → HCID 89815111, compound

HRID 1487115Notes

Reaction equation

HRID 1487115 reaction equation
[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3](OCC)=[O:4].[NH3:18]>>[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3]([NH2:18])=[O:4]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 53419335Benzeneacetic acid, α,α-difluoro-3-nitro-, ethyl ester

Product 1

HCID 89815111HCID 89815111, compound

Conditions

Temperature
75 °C

Procedure

A solution of ethyl 2,2-difluoro-2-(3-nitrophenyl)acetate (0.701 g, 2.86 mmol) in Methanolic ammonia (7M, 20.0 ml) was taken in sealed tube. Resulting mixture was heated at 75° C. for 3 hrs. The reaction mixture was concentrated under vacuum and cold water was added to obtain the precipitate. Solid was filtered to obtain 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.515 g).

Workup

  1. customResulting mixture
  2. concentrationThe reaction mixture was concentrated under vacuum and cold water
  3. additionwas added
  4. customto obtain the precipitate
  5. filtrationSolid was filtered

Sources & evidence

ORD record
ord-8c95057f9b114a829ccbb2c6e29538df
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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