Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Benzeneacetic acid, α,α-difluoro-3-nitro-, ethyl ester | HCID 53419335 | — |
| Product | HCID 89815111 | HCID 89815111 | — |
Reaction Steps
A solution of ethyl 2,2-difluoro-2-(3-nitrophenyl)acetate (0.701 g, 2.86 mmol) in Methanolic ammonia (7M, 20.0 ml) was taken in sealed tube. Resulting mixture was heated at 75° C. for 3 hrs. The reaction mixture was concentrated under vacuum and cold water was added to obtain the precipitate. Solid was filtered to obtain 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.515 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09428499B2 |
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| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-8c95057f9b114a829ccbb2c6e29538df |
|---|
| Source note | uspto-grants-2016_08 |
|---|
