HCID 80107846, compound → HCID 80108036, compound

HRID 1487125Notes

Reaction equation

HRID 1487125 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[C:7]([NH:9][CH:10]1[CH2:13][O:12][CH2:11]1)=[O:8])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[C:7]([NH:9][CH:10]1[CH2:13][O:12][CH2:11]1)=[O:8]

Participants

4

Reactant 1

HCID 80107846HCID 80107846, compound

Product 1

HCID 80108036HCID 80108036, compoundYield 92.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×

Procedure

To a stirred solution of 3-Nitro-N-(oxetan-3-yl)benzamide (0.06 g, 0.270 mmol) in methanol (5 ml) was added Pd/C (2.87 mg) and the reaction mixture was stirred under hydrogen atmosphere for 20 min. The reaction mixture was diluted with methanol (10 ml) and the mixture was filtered through celite, and the filtrate was concentrated under vacuum to afford the title compound (48 mg).

Workup

  1. filtrationthe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-8d514fff05fe4afcab73060429d99e1e
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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