HCID 89828081, compound → HCID 89828080, compound

HRID 1487133Notes

Reaction equation

HRID 1487133 reaction equation
[N:1]1([C:5](=[O:16])[CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=O)[CH:8]=2)[CH2:4][CH2:3][CH2:2]1>CO.[Pd]>[NH2:13][C:9]1[CH:8]=[C:7]([CH2:6][C:5]([N:1]2[CH2:4][CH2:3][CH2:2]2)=[O:16])[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 89828081HCID 89828081, compound

Product 1

HCID 89828080HCID 89828080, compoundYield 78.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-(Azetidin-1-yl)-2-(3-nitrophenyl)ethanone (0.5 g, 2.27 mmol) was taken in methanol (20 ml) and at 0° C., Pd—C (10%, 0.05 g) was added. The reaction mixture was stirred under hydrogen atmosphere at room temperature for 5 hrs. The reaction mixture was filtered through celite and the filtrate was concentrated under vacuum to afford the title product (0.34 gm).

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-aaf26266adbe45768784972f8776954c
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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