HCID 89815274, compound → HCID 80108274, compound

HRID 1487135Notes

Reaction equation

HRID 1487135 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][CH:14]2[CH2:17][O:16][CH2:15]2)=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][CH:14]2[CH2:17][O:16][CH2:15]2)=[O:12])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 89815274HCID 89815274, compound

Product 1

HCID 80108274HCID 80108274, compoundYield 96.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-(3-Nitrophenyl)-N-(oxetan-3-yl)acetamide (0.5 g, 2.11 mmol) was taken in methanol (20 ml) and at 0° C., 10% Pd—C (0.5 g) was added. The reaction mixture was stirred under hydrogen atmosphere at room temperature for 5 hrs. The reaction mixture was filtered through celite and the filtrate was concentrated under vacuum to afford the title product (0.42 gm).

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-4596d39689fc4d45b7be6c918e725d2d
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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