HCID 89828092, compound → HCID 89828093, compound

HRID 1487137Notes

Reaction equation

HRID 1487137 reaction equation
[OH:1][CH:2]1[CH2:5][N:4]([C:6](=[O:17])[CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=2)[CH2:3]1>CO.[Pd]>[NH2:14][C:10]1[CH:9]=[C:8]([CH2:7][C:6]([N:4]2[CH2:3][CH:2]([OH:1])[CH2:5]2)=[O:17])[CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 1

HCID 89828092HCID 89828092, compound

Product 1

HCID 89828093HCID 89828093, compoundYield 96.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-(3-hydroxyazetidin-1-yl)-2-(3-nitrophenyl)ethanone (0.5 g, 2.117 mmol) was taken in methanol (20 ml) and at 0° C., Pd—C (10%, 0.5 g) was added. The reaction mixture was stirred under hydrogen atmosphere at room temperature for 5 hrs. The reaction mixture was filtered through celite and the filtrate was concentrated under vacuum to afford the title product (0.42 gm).

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-5c9f3df46b0e452ba0268057cc5e3227
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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