Hydrochloric Acid → HCID 65450578, compound

HRID 1487139Notes

Reaction equation

HRID 1487139 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[C:7]([NH:9][C:10]1([C:13]([O:15]CC)=[O:14])[CH2:12][CH2:11]1)=[O:8])([O-:3])=[O:2].[OH-].[Na+].Cl>C(O)C.O>[N+:1]([C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[C:7]([NH:9][C:10]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]1)=[O:8])([O-:3])=[O:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 89815426HCID 89815426, compound

Product 1

HCID 65450578HCID 65450578, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To the solution of ethyl 1-(3-nitrobenzamido)cyclopropanecarboxylate (0.5 g, 1.797 mmol) in ethanol 10 ml, sodium hydroxide (aq) (5 ml, 25.00 mmol) was added and stirred at room temperature for 10 hr. Reaction mixture was diluted with water (20 ml), and acidified by adding 5N HCl. Obtained white precipitates were filtered. The residue was dried by azetrope with toluene (0.38 g, 85%).

Workup

  1. customReaction mixture
  2. customObtained white
  3. customprecipitates
  4. filtrationwere filtered
  5. dry with materialThe residue was dried by azetrope with toluene (0.38 g, 85%)

Sources & evidence

ORD record
ord-3ab38f7213894e4db390453e39254dc4
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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