HCID 89815500, compound → HCID 89815390, compound

HRID 1487141Notes

Reaction equation

HRID 1487141 reaction equation
[C:1]([C:4]1([NH:7][C:8](=[O:18])[C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=2)[CH2:6][CH2:5]1)(=[O:3])[NH2:2]>CO.[Pd]>[NH2:15][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=1)[C:8]([NH:7][C:4]1([C:1](=[O:3])[NH2:2])[CH2:6][CH2:5]1)=[O:18]

Participants

4

Reactant 1

HCID 89815500HCID 89815500, compound

Product 1

HCID 89815390HCID 89815390, compoundYield 81.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To the suspension of N-(1-carbamoylcyclopropyl)-3-nitrobenzamide (0.28 g, 1.123 mmol) in methanol (5 ml), Pd—C (0.05 g) was added under nitrogen and stirred the reaction mixture under hydrogen atmosphere at room temperature. After 2 hr, reaction mixture was filtered and concentrated under vacuum to afford solid compound (0.2 g, 81%).

Workup

  1. additionwas added under nitrogen
  2. customreaction mixture
  3. filtrationwas filtered
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-2a8f3d11add44893b0778a8a229e104b
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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