反应详情

To a solution of morpholino(3-nitrophenyl)methanone (2 g, 8.47 mmol) in Ethyl acetate (40 ml) was added tin(II) chloride dehydrate (7.64 g, 33.9 mmol). Resulting reaction mixture was stirred at RT for 17 h. The reaction mixture was neutralized with NaOH (2N), the mixture was filtered and the filtrate was extracted with Ethyl acetate (250 ml×2). The combined organic layer was washed with brine, dried over sodium sulphate and concentrated under vacuum to give the title product (1.4 g).

1. customResulting
2. customreaction mixture
3. filtrationthe mixture was filtered
4. extractionthe filtrate was extracted with Ethyl acetate (250 ml×2)
5. washThe combined organic layer was washed with brine
6. dry with materialdried over sodium sulphate
7. concentrationconcentrated under vacuum