反应详情

To a stirred solution of 2-methyl-2-(3-nitrophenoxy)propanamide (0.910 g, 4.06 mmol) in MeOH (15 ml) was added Pd—C (10%, 0.346 g) and triethylsilane (6.48 ml, 40.6 mmol) (slow addition) at room temperature. The reaction mixture was stirred at same temperature for 30 min. and filtered through celite, washed with methanol (50 ml). The Filtrate was concentrated under vacuum to get the crude compound. The crude compound was purified by flash chromatography to give the title product (0.516 g).

1. filtrationfiltered through celite
2. washwashed with methanol (50 ml)
3. concentrationThe Filtrate was concentrated under vacuum
4. customto get the crude compound
5. customThe crude compound was purified by flash chromatography