反应详情

A suspension of (S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid (5 g, 25 mmol) and urea (1.8 g, 29.4 mmol) in acetic anhydride (15 mL) was placed in a microwave reactor and allowed to react under microwave irradiation at 60° C. for 30 minutes. After cooled to room temperature, the mixture was quenched by sodium bicarbonate and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate, concentrated and purified by silica gel chromatography to afford the product (S)-ethyl 2-(2,4,6-trioxohexahydropyrimidin-5-yl)propanoate (2.85 g, yield 50%).

1. customwas placed in a microwave reactor
2. customto react under microwave irradiation at 60° C. for 30 minutes
3. customthe mixture was quenched by sodium bicarbonate
4. extractionextracted with ethyl acetate
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated
7. custompurified by silica gel chromatography