Water → 2-Chloro-3-hydrazinopyrazine

HRID 1487265Notes

Reaction equation

HRID 1487265 reaction equation
[Cl:1][C:2]1[C:7](Cl)=[N:6][CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11].O>C(O)C>[Cl:1][C:2]1[C:7]([NH:10][NH2:11])=[N:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 785752,3-Dichloropyrazine

Product 1

HCID 3214302-Chloro-3-hydrazinopyrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

2,3-Dichloropyrazine A-1 (15 g; 100.68 mmol) and hydrazine hydrate 65% (15.509 ml; 201.37 mmol) are dissolved in 45 ml ethanol and stirred for 1 h at 80° C. While cooling down, a precipitate is formed. It is slurred up with a small amount of water and filtered off. It is washed with water and then dried to afford the product.

Workup

  1. temperatureWhile cooling down
  2. customa precipitate is formed
  3. filtrationfiltered off
  4. washIt is washed with water
  5. customdried
  6. customto afford the product

Sources & evidence

ORD record
ord-c2da6fa2abc24bdeaa6ee90ba79f71c3
Source dataset
uspto-grants-2016_08
Patent number
US09428513B2

Reaction notes

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