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HRID1487274

反应详情

EQUATION

反应方程式

HRID 1487274 的结构方程式

REACTANTS

反应物

1
反应SMILES：COC[C@H](C)Nc1cc2c(cc1NC(=O)c1cc(C)c(=O)n(C)c1)C(C)(C)C(=O)N2C
HCID118509711

未命名化合物

PRODUCTS

产物

1
反应SMILES：COC[C@H](C)n1c(-c2cc(C)c(=O)n(C)c2)nc2cc3c(cc21)N(C)C(=O)C3(C)C
HCID118499922

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

CONDITIONS

反应条件

温度
150 °C

PROCEDURE

实验过程

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid [6-((S)-2-methoxy-1-methyl-ethylamino)-1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl]-amide I-1′ (110 mg; 0.26 mmol) is dissolved in 2 ml acetic acid and stirred at 150° C. for 1 h. The solvent is evaporated and the crude product is purified using reversed phase chromatography (Method: prep. HPLC1).

WORKUP

后处理

  1. customThe solvent is evaporated
  2. customthe crude product is purified