HCID 118509711, compound → HCID 118499922, compound

HRID 1487274Notes

Reaction equation

HRID 1487274 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]([NH:6][C:7]1[CH:15]=[C:14]2[C:10]([C:11]([CH3:19])([CH3:18])[C:12](=[O:17])[N:13]2[CH3:16])=[CH:9][C:8]=1[NH:20][C:21]([C:23]1[CH:28]=[C:27]([CH3:29])[C:26](=[O:30])[N:25]([CH3:31])[CH:24]=1)=O)[CH3:5]>C(O)(=O)C>[CH3:31][N:25]1[C:26](=[O:30])[C:27]([CH3:29])=[CH:28][C:23]([C:21]2[N:6]([C@@H:4]([CH3:5])[CH2:3][O:2][CH3:1])[C:7]3[C:8]([N:20]=2)=[CH:9][C:10]2[C:11]([CH3:19])([CH3:18])[C:12](=[O:17])[N:13]([CH3:16])[C:14]=2[CH:15]=3)=[CH:24]1

Participants

3

Reactant 1

HCID 118509711HCID 118509711, compound

Product 1

HCID 118499922HCID 118499922, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
150 °C

Procedure

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid [6-((S)-2-methoxy-1-methyl-ethylamino)-1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl]-amide I-1′ (110 mg; 0.26 mmol) is dissolved in 2 ml acetic acid and stirred at 150° C. for 1 h. The solvent is evaporated and the crude product is purified using reversed phase chromatography (Method: prep. HPLC1).

Workup

  1. customThe solvent is evaporated
  2. customthe crude product is purified

Sources & evidence

ORD record
ord-cbb840ea31f94bc48dc12b8f7132f775
Source dataset
uspto-grants-2016_08
Patent number
US09428515B2

Reaction notes

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