反应详情

温度

110 °C

30.7 ml (329 mmol) of phosphorus oxychloride at 0° C. and 6 drops of sulfuric acid are added to 9 g (6.6 mmol) of 2-hydroxy-5-iodonicotinonitrile. The reaction mixture is heated at 110° C. for 5 hours and then at room temperature overnight. The reaction mixture is poured in a beaker containing ice and a little water, and a precipitate is formed. The mixture is allowed to gradually return to room temperature and then is filtered and rinsed with water. The solid is dried to yield 6.8 g (70%) of 2-chloro-5-iodonicotinonitrile.

1. customat room temperature
2. customovernight
3. additionThe reaction mixture is poured in a beaker
4. additioncontaining ice
5. customto gradually return to room temperature
6. filtrationis filtered
7. washrinsed with water
8. customThe solid is dried