Hydrochloric Acid → 3-Amino-6-iodopyrazine-2-carbonitrile

HRID 1487356Notes

Reaction equation

HRID 1487356 reaction equation
Cl.[C:2]([C:4]1[C:5]([N:11]=CN(C)C)=[N:6][CH:7]=[C:8]([I:10])[N:9]=1)#[N:3]>>[NH2:11][C:5]1[C:4]([C:2]#[N:3])=[N:9][C:8]([I:10])=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86680553N'-(3-cyano-5-iodopyrazin-2-yl)-N,N-dimethylformimidamide

Product 1

HCID 866805543-Amino-6-iodopyrazine-2-carbonitrileYield 95.3%

Conditions

Temperature
50 °C

Procedure

77 ml (77 mmol) of 1 M hydrochloric acid solution is added to 7.7 g (25.6 mmol) of N′-(3-cyano-5-iodopyrazin-2-yl)-N,N-dimethylformimidamide. The reaction medium is heated at 50° C. for 4 hours and then stirred at room temperature overnight. The precipitate formed is filtered, rinsed with water and dried at 50° C. to yield 6 g (95%) of 3-amino-6-iodopyrazine-2-carbonitrile in the form of a beige solid.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered
  3. washrinsed with water
  4. customdried at 50° C.

Sources & evidence

ORD record
ord-22b54a6c060f4a12853a7ca93871fe84
Source dataset
uspto-grants-2016_08
Patent number
US09428510B2

Reaction notes

Loading…