Hydrazine → HCID 178509238, compound

HRID 1487382Notes

Reaction equation

HRID 1487382 reaction equation
[NH2:1][NH2:2].Cl[C:4]1[N:9]=[CH:8][C:7]([S:10]([NH:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([F:21])[CH:15]=2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:22]#[N:23]>C(O)(C)C>[NH2:23][C:22]1[C:5]2[C:4](=[N:9][CH:8]=[C:7]([S:10]([NH:13][C:14]3[CH:15]=[C:16]([F:21])[CH:17]=[C:18]([F:20])[CH:19]=3)(=[O:12])=[O:11])[CH:6]=2)[NH:2][N:1]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86680560HCID 86680560, compound

Product 1

HCID 178509238HCID 178509238, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
75 °C

Procedure

0.377 ml (2.63 mmol) of 35% hydrazine is added to 0.217 g (0.658 mmol) of 6-chloro-5-cyano-N-(3,5-difluorophenyl)pyridine-3-sulfonamide diluted in 6 ml of isopropanol. The solution is heated at 75° C. for 2 hours. The solvent is evaporated to yield 0.214 g of 3-amino-N-(3,5-difluorophenyl)-1H-pyrazolo[3,4-b]pyridine-5-sulfonamide in the form of a yellow solid (yield=100%).

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-736c0f0c8a1949efac6fa0629fd4bd33
Source dataset
uspto-grants-2016_08
Patent number
US09428510B2

Reaction notes

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