反应详情

温度

90 °C

To a solution of (4S,5R)-4-Fluoromethyl-2,2-dimethyl-5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-oxazolidine-3-carboxylic acid tert-butyl ester (270 mg, 0.620 mmol) in dimethoxyethane:water (8:2, 3.6 mL) is added Cs2CO3 (504 mg, 1.55 mmol) and (5-Bromo-pyridin-2-ylmethyl)-isopropyl-amine (156 mg, 0.682 mmol) at room temperature. Reaction mixture is degassed with nitrogen for 30 minutes then Pd(PPh3)4 (71 mg, 0.062 mmol) is added. The resulting reaction mixture is heated to 90° C. for 4 hours. The reaction mixture is diluted with water and ethyl acetate. The organic layer is separated, dried over sodium sulphate and solvent is evaporated in vacuo. The crude is purified by column chromatography eluting in 5% methanol in CH2Cl2 to afford the title compound (100 mg). LC-MS (m/z): [M+H]=458.2.

1. customReaction mixture
2. customis degassed with nitrogen for 30 minutes
3. customThe resulting reaction mixture
4. customThe organic layer is separated
5. dry with materialdried over sodium sulphate and solvent
6. customis evaporated in vacuo
7. customThe crude is purified by column chromatography
8. washeluting in 5% methanol in CH2Cl2