Triphenylphosphine → (4-Benzyloxy-phenyl)-(6-furan-2-yl-quinazolin-4-yl)-amine

HRID 148754Notes

Reaction equation

HRID 148754 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([NH:15][c:16]2[n:17][cH:18][n:19][c:20]3[cH:21][cH:22][c:23]([Br:26])[cH:24][c:25]23)[cH:13][cH:14]1.[CH2:27]([Sn:28]([CH2:29][CH2:30][CH2:31][CH3:37])([c:32]1[o:33][cH:34][cH:35][cH:36]1)[CH2:38][CH2:39][CH2:40][CH3:41])[CH2:42][CH2:43][CH3:44].[O:45]1[CH2:46][CH2:47][O:48][CH2:49][CH2:50]1.[Pd:51]([Cl:52])[Cl:53].[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1.[c:73]1([P:74]([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[cH:87][cH:88][cH:89][cH:90][cH:91]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([NH:15][c:16]2[n:17][cH:18][n:19][c:20]3[cH:21][cH:22][c:23](-[c:32]4[o:33][cH:34][cH:35][cH:36]4)[cH:24][c:25]23)[cH:13][cH:14]1

Participants

6

Reactant 5

HCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 312751,4-DioxaneHCID 1569266(6-Bromoquinazolin-4-yl)[4-(phenylmethoxy)phenyl]amineHCID 43936882-(Tributylstannyl)furan

Product 1

HCID 22609796(4-Benzyloxy-phenyl)-(6-furan-2-yl-quinazolin-4-yl)-amine

Sources & evidence

ORD record
ord-c40490eb8e4e438a822496a162f1b8e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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