HCID 86726494, compound → HCID 86726495, compound

HRID 1487661Notes

Reaction equation

HRID 1487661 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]([N@@:14]2[CH2:16][CH:15]2[CH3:17])=[O:13])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>CO.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([C:12]([N@@:14]2[CH2:16][CH:15]2[CH3:17])=[O:13])=[CH:4][C:3]=1[O:2][CH3:1]

Participants

4

Reactant 1

HCID 86726494HCID 86726494, compound

Product 1

HCID 86726495HCID 86726495, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (R)-(3-methoxy-4-nitrophenyl)(2-methylaziridin-1-yl)methanone (1 equiv) in MeOH (0.22 M) was added 10% palladium on carbon (18 weight %). The reaction was stirred at room temperature for 1 h under hydrogen. The mixture was filtered through a pad of celite and concentrated to give the desired product (94% yield) as a white solid. MS (ESI) m/z 207.1 [M+H]+.

Workup

  1. filtrationThe mixture was filtered through a pad of celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-a543489794f948599de701e3a7312884
Source dataset
uspto-grants-2016_08
Patent number
US09428509B2

Reaction notes

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