反应详情

温度

80 °C

To a suspension of 1-ethyl-4-nitro-1H pyrazole (1 equiv) and iron dust (5 equiv) in EtOH (0.285 M) was added ammonium chloride (10 equiv). The mixture was heated to 80° C. for 20 h then cooled to room temperature. The solvent was removed under reduced pressure to give crude material that was purified by silica gel chromatography (1.5% MeOH in DCM) to provide the desired product (30% yield) as a yellow oil. MS (ESI) m/z 146.0 [M+H]+.

1. temperaturethen cooled to room temperature
2. customThe solvent was removed under reduced pressure
3. customto give crude material that
4. customwas purified by silica gel chromatography (1.5% MeOH in DCM)